Effects of the Addition of Aminosilane-Functionalized Titanate Nanotubes in Carboxymethylcellulose-Based Film for Biomedical Applications

Resumo

© 2025 The Author(s). Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.Skin injuries occur when cellular integrity is compromised due to mechanical, physical, or metabolic factors. This study reported on a carboxymethylcellulose (CMC)-based film incorporating TiNT, aiming at its application as a wound dressing. As a minimally invasive approach, titanate nanotubes (TiNT) have been studied due to their photocatalytic properties, biocompatibility, large pore volume, and high surface area. Functionalization with aminosilane groups, using the biological responses of nitrogen, has been explored to enhance cellular interaction. Upon exposure to UV radiation, the dressing releases nanotubes, protecting the lesion from external pathogens and promoting healing. TiNTs were synthesized via a hydrothermal method and 0.2% (v/v) functionalized using 3-aminopropyltrimethoxysilane (APTMS). The films were prepared with 1 (wt%) TiNT or TiNT_NH2 in a 2 (wt%) CMC solution and dried at 60°C for 24 h. Results showed enhanced thermal stability and the potential for controlled nanoparticle release under UV light, with no cytotoxic effects observed. The films demonstrated excellent biocompatibility, making them promising candidates for medical applications.

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